Stoff	Diclofenac
Literaturtitel	Toxic effects of the non-steroidal anti-inflammatory drug diclofenac, Part I: histopathological alterations and bioaccumulation in rainbow trout
Organismus	Oncorhynchus mykiss
Habitat	Wasser
Prüfart	Histopathologie
Endpunkt	Histopathologie, Kiemen
Standard
Dauer Parameter Wert Bezug nominal / analytisch 28  d NOEC 1  µg/l ana Dauer (norm.) Wert (norm.) 28  d NOEC 1  µg/l ana
Testmedium	Süßwasser
pH	7,4	Temperatur	10,3
Dynamik	durchfluss	Wasserhärte	21,2 dGH
Methodenlisting
Auswertung (Statistische Methode) ANOVA Konzentrationen 1, 5, 20, 100 und 500 µg Diclofenac/L Organismus Alter/Lebenstadium 1.8 years; (average body weight: 167.6 ± 20.28 g; average body length: 25.9 ± 1.04 cm) Organismus Anzahl 24 Endpunktangaben Degenerative and necrotic changes of the pillar cells as well as a dilation of the capillary walls. Severity of gill damage increased significantly after exposure to 5µg/L and higher diclofenac concentrations compared to the control level. Sauerstoffgehalt Oxygen saturation: 70% Lösevermittler DMSO, additional control group of fish exposed to 0.12‰ dimethylsulfoxid (DMSO)
Testbonität
2 / Klimisch